sharepoint intranet web application not connecting using sharpoint designer

I can not access our intranet portal from SharePoint designer 2010

1. I enabled anonymous access in IIS for SharePoint web application 
2. I enabled user permissions for User Remote Interfaces

it was worked before last two weeks 

![enter image description here][1]

this web application has below aam


Hi when i enable verbose i found that error:

    Exception returned from back end service. System.ServiceModel.ServerTooBusyException: The HTTP service located
     at http://spdv01:32843/d8223431896f4032a7e417eecf79819b/MetadataWebService.svc is too busy.  ---> System.Net.WebException: The remote server returned an error: (503) Server Unavailable.    
     at System.Net.HttpWebRequest.GetResponse()    
     at System.ServiceModel.Channels.HttpChannelFactory.HttpRequestChannel.HttpChannelRequest.WaitForReply(TimeSpan timeout)     -
     -- End of inner exception stack trace ---    Server stack trace:     
     at System.ServiceModel.Channels.HttpChannelUtilities.ProcessGetResponseWebException(WebException webException, HttpWebRequest request, HttpAbortReason abortReason)    
     at System.ServiceModel.Channels.HttpChannelFactory.HttpRequestChannel.HttpChannelRequest.WaitForReply(TimeSpan timeout)    
     at System.ServiceModel.Channels.RequestChannel.Request(Message message, TimeSpan timeout)    
     at System.ServiceModel.Channels.SecurityChannelFactory`1.SecurityRequestChannel.Request(Message message, TimeSpan timeout)    
     at System.ServiceModel.Dispatcher.RequestChannelBinder.Request(Message message, TimeSpan timeout)    
     at System.ServiceModel.Channels.ServiceChannel.Call(String action, Boolean oneway, ProxyOperationRuntime operation, Object[] ins, Object[] outs, TimeSpan timeout)    
     at System.ServiceModel.Channels.ServiceChannel.Call(String action, Boolean oneway, ProxyOperationRuntime operation, Object[] ins, Object[] outs)    
     at System.ServiceModel.Channels.ServiceChannelProxy.InvokeService(IMethodCallMessage methodCall, ProxyOperationRuntime operation)    
     at System.ServiceModel.Channels.ServiceChannelProxy.Invoke(IMessage message)    Exception rethrown
     at [0]:     
     at System.Runtime.Remoting.Proxies.RealProxy.HandleReturnMessage(IMessage reqMsg, IMessage retMsg)    
     at System.Runtime.Remoting.Proxies.RealProxy.PrivateInvoke(MessageData& msgData, Int32 type)    
     at Microsoft.SharePoint.Taxonomy.IMetadataWebServiceApplication.GetServiceSettings(Guid rawPartitionId)    
     at Microsoft.SharePoint.Taxonomy.MetadataWebServiceApplicationProxy.<>c__DisplayClass2f.<ReadApplicationSettings>b__2e(IMetadataWebServiceApplication serviceApplication)    
     at Microsoft.SharePoint.Taxonomy.MetadataWebServiceApplicationProxy.<>c__DisplayClass2c.<RunOnChannel>b__2b()

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adil