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Changes to Permissions has no effect

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Hi

I have a crisis I'd really appreciate some help with!

I have a SharePoint 2010 site collection that has been running fine, but today there's a major problem with Permissions.

First I found that no one except me - the Site Collection Admin - could create new pages. (They receive an Access Denied error.)

Then I found that changes I make to site permissions now have no effect. (I can add people to membership groups for sites, but it has no effect on which sites the users can then access.)

Last night I reconfigured the Permissions across the whole site. I cant see anything wrong with them now. The only thing I did that worries me is I removed permissions on a Service Account because I couldn't see why it was there. Now I cant recall the exact name of the service account or what permissions it had.

Help!

Stuart


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